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Quality and safety of research biopsies in oncology clinical trials.
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DOI：10.1016/j.ejca.2026.116819.png)
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Abstract
En 中文
• Ethical concerns have been raised about research biopsy collection in clinical trials. • In 3,104 procedures, major complications were observed in 28 (0.9%) cases. • Median tumour content of 70% with 82% of biopsies being adequate for analyses. • Collection of multiple samples improved quality without increasing complications. • Biopsies taken from visceral organs and after baseline increased major complications
Keywords:
research biopsies
safety
tumour content
ethics
precision oncology
clinical trials
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