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Quantifying reference alignment bias in functional genomics analyses
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DOI：10.1016/j.crmeth.2026.101461.png)
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Abstract
En 中文
• We provide a method for quantifying reference alignment bias in a genome-wide manner • 0.2%–3% of the genome is susceptible to bias when using human reference hg38 • Bias persists even with the use of the complete human reference CHM13 • Genome-wide quantification highlights problematic regions of RAB
Keywords:
functional genomics
genomics
genetics
RNA-seq
ATAC-seq
WGBS
CP: genetics
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