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Quantitative Image Analysis Reveals the Benefits of Dapagliflozin on Glomerulosclerosis, Podocyte Effacement and Kidney Fibrosis in the SDT Fatty Rat Model of Diabetic Nephropathy
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DOI：10.1016/j.ejps.2026.107588.png)
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Abstract
En 中文
We aimed to optimize drug efficacy studies in the Spontaneously Diabetic Torii (SDT) fatty rat, a type 2 diabetic model, using kidney histology image analysis with 1) quantitative glomerulosclerosis and tubular impairments (Nephropath AI), 2) Podocyte Exact Morphology Measurement Procedure (PEMP) and 3) quantitative digital pathology of fibrosis (FibroNest platform). To demonstrate the potential of our imaging methods, dapagliflozin for 10 weeks was evaluated in SDT fatty rats fed a 0.3% salt diet with unilateral nephrectomy (Unx). Sham operated SDT fatty and Sprague Dawley (SD) rats were used as controls.
Keywords:
diabetic nephropathy
glomerular filtration rate
rat
dapagliflozin
image analysis
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