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Quantitative Nonlinear Optical Assessment of Atherosclerosis Progression in Rabbits
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DOI：10.1021/ac5005635.png)
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Abstract
En 中文
Quantification of atherosclerosis has been a challenging task owing to its complex pathology. In this study, we validated a quantitative approach for assessing atherosclerosis progression in a rabbit model using a numerical matrix, optical index for plaque burden, derived directly from the nonlinear optical microscopic images captured on the atherosclerosis-affected blood vessel. A positive correlation between this optical index and the severity of atherosclerotic lesions, represented by the age of the rabbits, was established based on data collected from 21 myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits with age ranging between new-born and 27 months old. The same optical index also accurately identified high-risk locations for atherosclerotic plaque formation along the entire aorta, which was validated by immunohistochemical fluorescence imaging.
Keywords:
RAMAN SCATTERING MICROSCOPY
IN-VIVO CHARACTERIZATION
CELL-ADHESION MOLECULES
BLOOD-FLOW
VULNERABLE PLAQUE
VASCULAR-LESIONS
SHEAR-STRESS
ANIMAL-MODEL
E-SELECTIN
CORONARY
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