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Quantitative pharmacokinetics
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Abstract
En 中文
Quantitative pharmacokinetic analysis allows the mathematical description of the movement of drug around the body after administration. Numerical parameters such as volume of distribution, clearance and terminal half-life are used to describe this movement. These parameters are defined through pharmacokinetic analysis. There are a number of methods used for pharmacokinetic analysis. These include compartmental modelling, which divides the body into mathematical compartments and represents the movement of drugs between these. Compartmental models of intravenous anaesthetic pharmacokinetics can be used to explain the 'on-off' effect of propofol and context-specific half-time. Pharmacokinetic analysis has a number of clinical applications, such as dose adjustments for special populations and target-controlled infusions of anaesthetic agents.
Keywords:
Clearance
compartmental modelling
context-specific half-time
half-life
pharmacokinetics
target-controlled infusion
volume of distribution
Journal
A
IF:
0.3
Papers:
42
Citations:
0
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