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Radically Enhanced Dual Recognition
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DOI：10.1002/anie.202109647.png)
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Abstract
En 中文
Complexation between a viologen radical cation (V.+) and cyclobis(paraquat-p-phenylene) diradical dication (CBPQT(2(.+))) has been investigated and utilized extensively in the construction of mechanically interlocked molecules (MIMs) and artificial molecular machines (AMMs). The selective recognition of a pair of V.+ using radical-pairing interactions, however, remains a formidable challenge. Herein, we report the efficient encapsulation of two methyl viologen radical cations (MV.+) in a size-matched bisradical dicationic host - namely, cyclobis(paraquat-2,6-naphthalene)(2(.+)), i.e., CBPQN(2(.+)). Central to this dual recognition process was the choice of 2,6-bismethylenenaphthalene linkers for incorporation into the bisradical dicationic host. They provide the space between the two bipyridinium radical cations in CBPQN(2(.+)) suitable for binding two MV.+ with relatively short (3.05-3.25 angstrom) radical-pairing distances. The size-matched bisradical dicationic host was found to exhibit highly selective and cooperative association with the two MV.+ in MeCN at room temperature. The formation of the tetrakisradical tetracationic inclusion complex - namely, [(MV)(2)subset of CBPQN](4()(.+)) - in MeCN was confirmed by VT H-1 NMR, as well as by EPR spectroscopy. The solid-state superstructure of [(MV)(2)subset of CBPQN](4()(.+)) reveals an uneven distribution of the binding distances (3.05, 3.24, 3.05 angstrom) between the three different V.+, suggesting that localization of the radical-pairing interactions has a strong influence on the packing of the two MV.+ inside the bisradical dicationic host. Our findings constitute a rare example of binding two radical guests with high affinity and cooperativity using host-guest radical-pairing interactions. Moreover, they open up possibilities of harnessing the tetrakisradical tetracationic inclusion complex as a new, orthogonal and redox-switchable recognition motif for the construction of MIMs and AMMs.
Keywords:
binding stoichiometry
host-guest systems
molecular recognition
radical-pairing interactions
Journal
IF:
16.9
Papers:
5.7W
Citations:
53.0W
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