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RanGAP1 plays a vital role in anti-infective functions of macrophages and sepsis progression

delete2026-04-27
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PRE
AI
L
Linlin Mao
G
Genming Liu
J
Jiahuan Zhang
Q
Qiongzhi Zhao
X
Xinyi Zhang
S
Sheng Zhang
Y
Yue Zhang *
X
Xiaochun Bai *
DOI：10.1016/j.imlet.2026.107180delete
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Abstract

Abstract

En 中文
• LPS stimulation modulates the expression and subcellular localization of RanGAP1 in macrophages. • Loss of RanGAP1 attenuates essential macrophage-mediated host defense mechanisms. • Macrophage RanGAP1 deficiency accelerates disease progression and exacerbates severity in murine sepsis model.
Keywords:
RanGAP1
macrophages
sepsis
host defense
LPS stimulation

Journal

Immunology Letters cover
Immunology Letters
IF:
2.8
Papers:
4.5K
Citations:
6.1K

Organization

S
southern medical university
Scholars:
1.2W
Papers: 2.9K
Citations: 5
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