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Rate-dependent cochlear outer hair cell force generation: Models and parameter estimation
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DOI：10.1016/j.bpj.2024.08.007.png)
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Abstract
En 中文
The outer hair cells (OHCs) of the mammalian cochlea are the mediators of an active, nonlinear electromechanical process necessary for sensitive, frequency-specific hearing. The membrane protein prestin conveys to the OHC a piezoelectric-like behavior hypothesized to actuate a high frequency, cycle-by-cycle conversion of electrical to mechanical energy to boost cochlear responses to low-level sound. This hypothesis has been debated for decades, with two key remaining issues: the influence of the rate dependence of conformal changes in prestin and the OHC transmembrane impedance. In this paper, we mainly focus on the rate dependence of the conformal change in prestin. A theoretical electromechanical model of the OHC that explicitly includes rate dependence of conformal transitions, viscoelasticity, and piezoelectricity. Using this theory, we show the influence of rate dependence and viscoelasticity on electromechanical force generation and transmembrane impedance. Furthermore, we stress the importance of using the correct mechanical boundary conditions when estimating the transmembrane capacitance. Finally, a set of experiments is described to uniquely estimate the constitutive properties of the OHC from whole-cell measurements.
Keywords:
MECHANICAL RESPONSES
SOMATIC STIFFNESS
MEMBRANE MOTOR
MOTILITY
TRANSDUCTION
ELECTROMOTILITY
AMPLIFICATION
TRANSMISSION
CAPACITANCE
DYNAMICS
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