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Real-time 4D MRI using MR signature matching (MRSIGMA) on a 1.5T MR-Linac system
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DOI：10.1088/1361-6560/acf3cc.png)
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Abstract
En 中文
Objective. To develop real-time 4D MRI using MR signature matching (MRSIGMA) for volumetric motion imaging in patients with pancreatic cancer on a 1.5T MR-Linac system. Approach. Two consecutive MRI scans with 3D golden-angle radial stack-of-stars acquisitions were performed on ten patients with inoperable pancreatic cancer. The complete first scan (905 angles) was used to compute a 4D motion dictionary including ten pairs of 3D motion images and signatures. The second scan was used for real-time imaging, where each angle (275 ms) was processed separately to match it to one of the dictionary entries. The complete second scan was also used to compute a 4D reference to assess motion tracking performance. Dice coefficients of the gross tumor volume (GTV) and two organs-at-risk (duodenum-stomach and small bowel) were calculated between signature matching and reference. In addition, volume changes, displacements, center of mass shifts, and Dice scores over time were calculated to characterize motion. Main results. Total imaging latency of MRSIGMA (acquisition + matching) was less than 300 ms. The Dice coefficients were 0.87 & PLUSMN; 0.06 (GTV), 0.86 & PLUSMN; 0.05 (duodenum-stomach), and 0.85 & PLUSMN; 0.05 (small bowel), which indicate high accuracy (high mean value) and low uncertainty (low standard deviation) of MRSIGMA for real-time motion tracking. The center of mass shift was 3.1 & PLUSMN; 2.0 mm (GTV), 5.3 & PLUSMN; 3.0 mm (duodenum-stomach), and 3.4 & PLUSMN; 1.5 mm (small bowel). The Dice scores over time (0.97 & PLUSMN; [0.01-0.03]) were similarly high for MRSIGMA and reference scans in all the three contours. Significance. This work demonstrates the feasibility of real-time 4D MRI using MRSIGMA for volumetric motion tracking on a 1.5T MR-Linac system. The high accuracy and low uncertainty of real-time MRSIGMA is an essential step towards continuous treatment adaptation of tumors affected by real-time respiratory motion and could ultimately improve treatment safety by optimizing ablative dose delivery near gastrointestinal organs.
Keywords:
real-time
4D MRI
motion tracking
radiotherapy
MR-Linac
Journal
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3.4
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Citations:
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