Real-time intraocular pressure monitoring and responsive drug release in preclinical models by an all-polymer smart contact lens

Yuting Cai

doi:10.1126/scitranslmed.ads9541

Real-time intraocular pressure monitoring and responsive drug release in preclinical models by an all-polymer smart contact lens

2026-04-08

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DOI：10.1126/scitranslmed.ads9541

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Smart contact lenses have promise for the monitoring and treatment of conditions such as intraocular pressure changes in glaucoma. Many current smart lenses use electronic components that may compromise wearer comfort and safety. Here, Cai et al. designed a mechanically responsive, all-polymer contact lens system to detect changes in intraocular pressure and release one or more drugs at predetermined pressure thresholds. Their studies in ex vivo model eyes and in rabbits with ocular hypertension showed that the polymer lens reliably measured intraocular pressure compared with standard measurement tools and that the pressure-driven release of timolol or brimonidine provided a therapeutic effect similar to that of manually applied medicated eye drops. This preclinical study demonstrates that a simple mechanical mechanism has potential to provide on-demand drug delivery for glaucoma management. —Molly Ogle

Keywords:

smart contact lens

intraocular pressure monitoring

drug delivery

glaucoma

all-polymer system

Real-time intraocular pressure monitoring and responsive drug release in preclinical models by an all-polymer smart contact lens

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