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Recent criteria and simple rules agreed often on required sample size for developed clinical prediction models
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DOI：10.1016/j.jclinepi.2026.112461.png)
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Abstract
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Adequate sample size is essential to the development of new prediction models with binary outcomes. We aim to relate recent approaches to traditional rules of thumb (‘simple rules’) and assess agreement and differences in judging adequacy of sample size for developed prediction models.
Keywords:
sample size calculation
prediction model
uncertainty
critical appraisal
review
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