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Recent Progress in Solid-State Nanopores
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DOI：10.1002/adma.201704680.png)
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Abstract
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The solid-state nanopore has attracted much attention as a next-generation DNA sequencing tool or a single-molecule biosensor platform with its high sensitivity of biomolecule detection. The platform has advantages of processability, robustness of the device, and flexibility in the nanopore dimensions as compared with the protein nanopore, but with the limitation of insufficient spatial and temporal resolution to be utilized in DNA sequencing. Here, the fundamental principles of the solid-state nanopore are summarized to illustrate the novelty of the device, and improvements in the performance of the platform in terms of device fabrication are explained. The efforts to reduce the electrical noise of solid-state nanopore devices, and thus to enhance the sensitivity of detection, are presented along with detailed descriptions of the noise properties of the solid-state nanopore. Applications of 2D materials including graphene, h-BN, and MoS2 as a nanopore membrane to enhance the spatial resolution of nanopore detection, and organic coatings on the nanopore membranes for the addition of chemical functionality to the nanopore are summarized. Finally, the recently reported applications of the solid-state nanopore are categorized and described according to the target biomolecules: DNA-bound proteins, modified DNA structures, proteins, and protein oligomers.
Keywords:
DNA sequencing
nanopore devices
nanopore fabrication
solid-state nanopores
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26.8
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3.4W
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46.0W
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Cited Papers
ShareSaveShareSaveRapid fabrication of uniformly sized nanopores and nanopore arrays for parallel DNA analysis.png)
ADVANCED MATERIALS
ADVANCED MATERIALSIF26.8
PREAI
ShareSaveThreading Immobilized DNA Molecules through a Solid-State Nanopore at >100 μs per Base RateACS NANO
OAAI
ACS NANOIF16
OAAIShareSaveAsymmetric dynamics of DNA entering and exiting a strongly confining nanoporeNATURE COMMUNICATIONS
OAAI
NATURE COMMUNICATIONSIF15.7
OAAIShareSaveElectrostatic focusing of unlabelled DNA into nanoscale pores using a salt gradientNATURE NANOTECHNOLOGYOAAI
NATURE NANOTECHNOLOGYIF34.9
OAAIShareSaveHybrid pore formation by directed insertion of α-haemolysin into solid-state nanoporesNATURE NANOTECHNOLOGYOAAI
NATURE NANOTECHNOLOGYIF34.9
OAAIShareSaveElectrophoretic Force on a Protein-Coated DNA Molecule in a Solid-State NanoporeNANO LETTERS
NANO LETTERSIF9.1
PREAI
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