.png){kind=icon}
Return
Red flags for multiple system atrophy
.png){kind=icon}
OA
AI
DOI：10.1002/mds.21992.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
The clinical diagnosis Of Multiple system atrophy (MSA) is fraught with difficulty and there are no pathognomonic features to discriminate the parkinsonian variant (MSA-P) from Parkinson's disease (PD). Besides the poor response to levodopa, and the additional presence of pyramidal or cerebellar signs (ataxia) or autonomic failure as major diagnostic criteria, certain other clinical features known as red flags or warning signs may raise the clinical suspicion of MSA. To study the diagnostic role of these features in MSA-P versus PD patients, a standardized red flag check list (RFCL) developed by the European MSA Study Group (EMSA-SG) was administered to 57 patients with probable MSA-P and 116 patients with probable PD diagnosed according to established criteria. Those red flags with a specifity over 95% were selected for further analysis. Factor analysis was applied to reduce the number of red flags. The resulting set was then applied to 17 patients with possible MSA-P who on follow-up fulfilled criteria of probable MSA-P. Red flags were grouped into related categories. With two or more of six red flag categories present specificity was 98.3% and sensitivity was 84.2% in our cohort. When applying these criteria to patients with possible MSA-P, 76.5% of them would have been correctly diagnosed as probable MSA-P 15.9 (+/- 7.0) months earlier than with the Consensus criteria alone. We propose a combination of two out of six red flag categories as additional diagnostic criteria for probable MSA-P. (C) 2008 Movement Disorder Society.
Keywords:
multiple system atrophy
diagnosis
red flags
warning signs
Journal
IF:
7.6
Papers:
1.1W
Citations:
3.3W
Organization
View more organizations
Cited Papers
The Privatization of Street Cheering Space by a Capital: A Case study of "Hyundai Fan Park 2010"
PREAI
ShareSaveMarked asymmetry of putaminal pathology in an MSA-P patient with Pisa syndrome.png)
MOVEMENT DISORDERS
MOVEMENT DISORDERSIF7.6
PREAI
ShareSave
ShareSaveShareSaveShareSaveDo published criteria improve clinical diagnostic accuracy in multiple system atrophy?NEUROLOGY
NEUROLOGYIF8.5
PREAI
ShareSaveShareSave View more