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Redox-responsive LNPs for therapeutics delivery
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DOI：10.1016/j.addr.2026.115934.png)
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Abstract
En 中文
• Redox-responsive lipid nanoparticles enable spatiotemporally controlled cargo release by coupling disease-specific GSH/ROS gradients with programmable structural transformations. • Rational integration of responsive motifs into LNP improves endosomal escape, delivery efficiency, and therapeutic potency of gene or drugs. • Emerging designs and targeting strategies position redox-LNPs as versatile platforms for developing precision medicine across cancer and non-cancer indications.
Keywords:
Redox responsiveness
LNPs
Gene/drug delivery
Journal
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17.6
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4.5K
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5.1W
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