.png){kind=icon}
.png){kind=icon}
Return
Reduced anti-TNFα autoantibody levels coincide with flare in systemic lupus erythematosus
.png){kind=icon}
PRE
AI
C
J
B
G
T
DOI：10.1016/j.jaut.2004.02.003.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Deviating cytokine patterns, as a consequence of aberrant immunoregulation, is implicated to be of actiopathogenetic importance in systemic lupus erythematosus (SLE). To evaluate the possibility of anti-cytokine autoantibody-mediated cytokine regulation/dysregulation, IgG class autoantibodies against cytokines (IL-1beta, IL-6, IL-10, TNFalpha and TGFbeta(1)) were analysed by enzyme-linked immunosorbent assay (ELISA) in serial serum samples from clinically well-characterized SLE patients and in normal human sera (NHS). Anti-TNFalpha autoantibody levels were lower in patients with active disease compared to inactive disease (P<0.001) as well as to NHS (P<0.001). The anti-TNFalpha antibody levels correlated inversely to the SLE disease activity index (SLEDAI) (r(2)=0.07, P<0.01), whereas anti-TGF beta antibodies were raised in SLE and correlated positively to levels of complement factor Clq (r(2)=0.08, P<0.005). Generally raised anti-cytokine antibody levels and correlations to disease activity measures were found in one individual. Inverse correlations were found comparing SLEDAI scores and autoantibodies to TNFalpha (r(2)=0.92) and IL-6 (r(2)=0.86) and positive correlations were found between levels of anti-TNFalpha and Clq (r(2)=0.86) and C3 (r(2)=0.90). We show, for the first time, a coincidence between reduced anti-TNFalpha autoantibody levels and disease exacerbation in SLE, which is of interest regarding aetiopathogenesis and disease control. (C) 2004 Elsevier Ltd. All rights reserved.
Keywords:
anti-cytokine antibodies
disease activity
immunoregulation
systemic lupus erythematosus
SLEDAI
tumour necrosis factor alpha
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
7
Papers:
3.1K
Citations:
1.0W
Organization
No organization information available
Cited Papers