Reduced myocardial NRG-1/ErbB4 signaling is associated with STING-linked macrophage pyroptotic signaling in sepsis-induced cardiac injury

2026-06-20

PRE

Yanian Wei

QianWen Wang

Cheng Shen

Xia Pan

Wen Kang

Long Wang *

DOI：10.1016/j.intimp.2026.117044

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• CLP suppresses myocardial NRG-1/ErbB4 signaling in septic mice. • rNRG-1 improves cardiac function and survival after polymicrobial sepsis. • rNRG-1 limits macrophage infiltration and inflammasome activation. • rNRG-1 suppresses cGAS-STING signaling and macrophage pyroptosis. • AAV-STING overexpression blunts rNRG-1-mediated cardioprotection.

Reduced myocardial NRG-1/ErbB4 signaling is associated with STING-linked macrophage pyroptotic signaling in sepsis-induced cardiac injury

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