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Reduction-Alkylation Proteome Profiling (RAPP): A novel strategy for proteome-wide target identification

delete2026-06-28
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PRE
AI
Y
Yiying Wu
J
Jingwen Yan
Y
Yuting Chen
G
Guangyuan Liu
Y
Yuran Wang
Q
Qian Wang
L
Liangyu Pan
Y
Yuyu Zhang
P
Panpan Zhang *
W
Wei Zhang *
D
Dezhi Kong *
DOI:10.1016/j.aca.2026.345903delete
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Abstract

Abstract

En 中文
• A novel reduction-alkylation-based RAPP strategy for label-free drug target identification with mild, simple operation. • Complements TPP and broadens modification-free proteome-wide target profiling coverage. • Captures proteome-wide denaturation profiles via differential reductive alkylation.

Journal

Analytica Chimica Acta cover
Analytica Chimica Acta
IF:
6
Papers:
3.3W
Citations:
6.1W

Organization

H
Hebei Medical University
Scholars:
2.5K
Papers: 638
Citations: 4.2K