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Reduction of PDZK1 promotes diabetic kidney disease by modulating fatty acid uptake in proximal tubular epithelial cells

delete2026-07-31
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PRE
AI
L
Longyan Yang
Y
Yan Wang
D
Di Wang
L
Lijie Zhang
J
Jianbo Wu
Y
Yongsong Xu
R
Ruili Yin
Y
Yanan Cheng
J
Jianan Lang
L
Lingling Wei
K
Kun Li
M
Mengfei He
J
Jianduo An
X
Xiangjun Zeng
J
Jing Ke *
Q
Qianmei Sun *
D
Dong Zhao *
DOI：10.1016/j.metabol.2026.156720delete
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Abstract

Abstract

En 中文
• PDZ domain-containing protein 1 (PDZK1), an adaptor protein known for regulating ion transport in proximal tubules, also controls fatty acid uptake in DKD. • Mechanistically, PDZK1 directly binds FATP2, limits its trafficking to the plasma membrane, and thereby restrains fatty acid influx. • Pharmacological inhibition of FATP2 mimics the protective effect of PDZK1, alleviating tubulointerstitial injury. Targeting the PDZK1–FATP2 axis represents a precision strategy to halt or reverse DKD.

Journal

M
Metabolism-Clinical and Experimental
IF:
11.9
Papers:
9.6K
Citations:
2.1W

Organization

C
capital medical university
Scholars:
1.2W
Papers: 3.2K
Citations: 0
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