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Reflecting on barriers to continuous pharmaceutical crystallization

delete2025-09-01
delete0
PRE
AI
G
Giovanni Aprile
C
Cedric Devos
T
Thomas Vetter
G
Gerard Capellades
K
Kevin P. Girard
C
Christopher L. Burcham
V
Venkateswarlu Bhamidi
D
Daniel A. Green
T
Torsten Stelzer
R
Richard D. Braatz
A
Allan S. Myerson *
DOI：10.1038/s44286-025-00268-wdelete
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Abstract

Abstract

En 中文
This Comment explores why continuous crystallization, despite its success in other industries, remains underutilized in pharmaceutical manufacturing. Among other challenges, we highlight two core issues: the lack of off-the-shelf small-scale equipment with integrated monitoring tools, and the absence of compatible continuous downstream units for filtration and drying, both of which limit practical implementation.

Journal

N
Nature Chemical Engineering
IF:
0
Papers:
120
Citations:
0

Organization

No organization information available