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Reframing gestational diabetes mellitus through two new paradigms: Early detection and lifelong intergenerational follow-up
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DOI：10.1113/JP290546.png)
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Abstract
En 中文
Gestational diabetes mellitus (GDM) has traditionally been regarded as a transient metabolic disorder limited to pregnancy, with management directed primarily towards reducing obstetric and perinatal complications. Yet a growing body of evidence over the past two decades compels a fundamental redefinition. Two emerging paradigms expand the physiological and clinical understanding of GDM. The first recognizes early-onset GDM (e-GDM), diagnosed in the first trimester, as a severe metabolic phenotype reflecting pre-existing dysfunction. The second reinterprets GDM as a lifelong, intergenerational condition, a sentinel event marking heightened risk for chronic cardiometabolic disease in both mother and offspring. Together, these frameworks demand a transition from short-term obstetric management to long-term preventive physiology, integrating early diagnosis, mechanistic understanding, and intergenerational care. image
Keywords:
developmental programming
endothelium
fetal programming
gestational diabetes
intergenerational
placenta
Journal
J
IF:
4.4
Papers:
144
Citations:
0
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Cited Papers