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Relapse activity during pregnancy and the postpartum year is associated with accelerated disability progression in multiple sclerosis
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DOI：10.1016/j.msard.2025.106932.png)
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Abstract
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• Relapse occurred in approximately one-third of women during pregnancy or the postpartum year, peaking in the first postpartum trimester. • Spinal cord lesions before pregnancy and lack of or discontinued DMT were associated with an increased risk of relapse. • In natalizumab-treated women, relapse risk was lower when treatment was continued into the third trimester. • Relapse during pregnancy or the postpartum year was linked to accelerated disability progression, with sustained differences in EDSS at two years postpartum.
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