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Relationship of GDF15 with hepatic mitochondrial respiration is depending on the presence of fibrosis in obese individuals
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DOI：10.1016/j.metabol.2025.156391.png)
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Abstract
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• GDF15 associates negatively with whole-body and adipose tissue insulin sensitivity. • GDF15 correlates positively with hepatic mitochondrial respiration in persons without fibrosis. • GDF15 correlates negatively with hepatic mitochondrial respiration in humans with fibrosis. • Hepatic fibrosis abrogates the correlation of GDF15 with mitochondrial respiration.
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