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Replication and compartmentalization of Dobrava-Belgrade virus in the central nervous system
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DOI：10.1080/22221751.2026.2673649.png)
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Abstract
En 中文
A heart-transplant recipient developed fatal neurologic disease. High-throughput sequencing (HTS) identified Dobrava – Belgrade virus in central nervous system (CNS) and peripheral specimens. Genomic analyzes showed distinct viral populations across compartments, suggesting CNS tropism. This case highlights atypical infection presentations in immunosuppressed patients and underscores the diagnostic value of HTS.
Keywords:
Unbiased sequencing
neuroinvasive infection
solid organ transplantation
immuncompromised host
compartmentalized viral populations
orthohantavirus dobravaense
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