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Reproductive factors and mortality risk: insights from the Tehran Lipid and Glucose Study (TLGS)
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DOI：10.1186/s12958-026-01604-2.png)
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Abstract
En 中文
While reproductive history is recognized as a determinant of women’s long-term health, its impact on mortality risk remains poorly characterized. This study aimed to elucidate the association between key reproductive factors and subsequent all-cause and cause-specific mortality within the Tehran Lipid and Glucose Study (TLGS) population. We analyzed data from a prospective cohort of 5,165 women (aged ≥ 20 years) with a history of at least one pregnancy. Associations between reproductive factors and mortality were estimated using Cox proportional hazards regression models, adjusting for age, body mass index (BMI), smoking status, education, physical activity levels, diabetes history, hypertension history, and dyslipidemia. Over the follow-up period, 497 deaths were recorded, representing 9.6% of participants; 168 deaths were due to cardiovascular disease (CVD) and 96 to cancer, accounting for 33.8% and 19.4% of all deaths, respectively. Late menarche was associated with increased all-cause and cancer-related mortality, with adjusted hazard ratios (HRs) of 1.52 and 2.04, respectively. Recurrent abortion was associated with higher all-cause mortality (HR = 1.41; 95% CI: 1.12–1.77). Women with parity ≥ 3 had higher risks of all-cause, cardiovascular, and cancer-related mortality compared with those with parity 1–2. Reproductive characteristics, particularly late menarche, recurrent abortion, and high parity, were associated with increased long-term mortality risk. These findings support further investigation of reproductive characteristics as potential markers of long-term mortality risk.
Keywords:
Reproductive factors
All-cause mortality
Cardiovascular mortality
Tehran Lipid and Glucose Study (TLGS)
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