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Reprogramming the Tumor Microenvironment with Oxygen-Driven Nanomotors for Cuproptosis-Enhanced Immunotherapy

delete2026-08-11
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OA
AI
X
Xinyu Gu
S
Shen Shen
Y
Yuting He
C
Chen Xue
M
Minghang Zhang
Y
Yitao Fan
Z
Ziyi Xu
L
Lifan Zhang
Y
Yingda Xie
Z
Ziming Wang *
L
Li Li *
J
Juan Lu *
Q
Qingmiao Shi *
DOI:10.1016/j.mtbio.2026.103540delete
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Abstract

Abstract

En 中文
• A self-propelling and oxygen-generating nanomotor is engineered for active tumor penetration and hypoxia alleviation. • Synergistic photothermal-cuproptosis therapy triggers potent immunogenic cell death. • Multi-stimuli-responsive drug release ensures spatiotemporal precision. • Robust systemic anti-tumor immunity suppresses both primary and metastatic tumors. • Initiates an immunomodulatory chain reaction triggered by cuproptosis to reverse immunosuppression.
Keywords:
cancer immunotherapy
tumor microenvironment
cuproptosis
nanomotors
photothermal therapy
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Materials Today Bio cover
Materials Today Bio
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10.2
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T
the first affiliated hospital of zhengzhou university
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Henan Provincial People's Hospital
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henan university of science and technology
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zhejiang university
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