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Repurposing Salmon Calcitonin for Glioblastoma treatment: Targeting YAP/TAZ via Hippo pathway activation

delete2026-06-05
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OA
AI
J
Jayita Goswami
P
Prithviraj Uttarasili
L
Lakshay Garg
K
Kaval Reddy Prasasvi
A
Abhishek Chowdhury
S
Subhrodeep Saha
J
Jayanta Chatterjee
A
Anand Srivastava *
K
Kumaravel Somasundaram *
DOI：10.1093/noajnl/vdag152delete
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Abstract

Abstract

En 中文
Glioblastoma (GBM) remains a deadly brain tumor. Activation of the wild-type calcitonin receptor (CTR) by salmon calcitonin (sCT) suppresses glioma growth, whereas patient-derived CTR mutants drive tumor progression and correlate with poor survival. This study delineates the mechanisms underlying sCT-mediated tumor suppression and reveals structural defects in oncogenic CTR variants.

Journal

N
Neuro-Oncology Advances
IF:
4.1
Papers:
1.5K
Citations:
3.2K

Organization

I
Indian Institute of Science
Scholars:
1.4K
Papers: 604
Citations: 1.3W
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