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Resistance to Silicosis Progression in Mice with Ch25h Downregulation: The Involvement of NLRP3 Inflammasome
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DOI：10.1016/j.biocel.2025.106861.png)
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Abstract
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• Inhalation of silica elevates Ch25h expression in lung. • Ch25h downregulation ameliorates pulmonary damage and fibrosis in silicosis model. • Ch25h activates NLRP3 inflammasome and pyroptosis in lung macrophages. • Ch25h knockdown suppresses ASC oligomerization to block NLRP3 inflammasome activation.
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