1
Return

Resolvin D1 alleviates periodontitis by promoting FPR2-dependent macrophage pro-resolving polarization and efferocytosis

delete2026-08-08
delete0
delete
OA
AI
X
Xuan-Xuan Yu
Z
Zi-Yao Zhuang
R
Rui-Yang Ge
S
Shuang Lin
J
Jiang-Yan Ren
Y
Yi-Wen Zhou
J
Jing-Lun Zhang
Z
Zixuan Li
G
Gefei Li
F
Fuhua Yan *
李
李晖 (Li Huang) *
J
Jie Deng *
DOI：10.1016/j.jare.2026.08.001delete
deleteOriginal
deleteOriginal request for help
deleteShare
deleteSave
Abstract

Abstract

En 中文
• Human periodontitis exhibits a resolution-deficient immune landscape marked by impaired efferocytosis and reduced RvD1 biosynthesis. • FPR2 is required for RvD1-mediated periodontal protection, as demonstrated in myeloid-specific Fpr2 knockout models. • Single-cell profiling reveals that RvD1 reprograms monocyte–macrophage states toward a pro-resolving phenotype in alveolar bone. • RvD1 promotes inflammatory resolution by inhibiting the p38 MAPK–ADAM17 axis and preserving CD14-dependent efferocytosis. • RvD1 restores macrophage efferocytotic function, supporting its therapeutic potential for periodontitis and chronic inflammatory diseases.
Keywords:
Periodontitis
Resolvin D1
Efferocytosis
Macrophage
Formyl peptide receptor 2
Inflammation resolution

Journal

Journal of Advanced Research cover
Journal of Advanced Research
IF:
13
Papers:
2.8K
Citations:
1.4W

Organization

N
nanjing university
Scholars:
7.6W
Papers: 5.5W
Citations: 87
N
nanjing forestry university
Scholars:
3.9K
Papers: 1.4K
Citations: 0
Cited Papers

Cited Papers

Citing Papers

Citing Papers