Solute clustering-mediated strengthening in an age-hardening-insensitive AZ31 magnesium alloy

Bing-Yu Wang

doi:10.1016/j.scriptamat.2026.117480

Resolving drug uptake heterogeneity in 3D organ on chip models via live single-cell microsampling and ion mobility mass spectrometry

2026-08-03

0

OA

AI

V

Vincent Lennard Verschoor

L

Laura Ann Castaneda

A

Arnaud Nicolas

B

Bas Trietsch

T

Thomas Hankemeier *

A

Ahmed Ali *

DOI：10.1016/j.aca.2026.346065

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Abstract

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• An organ-on-chip platform was adapted to allow microsampling of single cells from 3D hepatocellular carcinoma models. • The extra cellular matrix effect was reduced by incorporating single-cell sample preparation and FAIMS. • Tamoxifen was successfully measured in single cells embedded in a organ-on-chip model that was exposed to a drug gradient. • The differences in drug abundance between cells correlated with their position relative to the drug channel were studied.

Resolving drug uptake heterogeneity in 3D organ on chip models via live single-cell microsampling and ion mobility mass spectrometry

Abstract

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Organization

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