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ReSPONDINg TACtically, degrading strategically
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DOI：10.1016/j.tips.2023.08.010.png)
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Abstract
En 中文
Targeted protein degradation has become a popular strategy to expand the druggable proteome, but therapeutic options for membrane proteins are limited. Sun et al. have now developed R-spondin chimeras (ROTACs) that effectively mediate lysosomal degradation of PD-L1, thus providing a modular platform that may be applicable to other membrane proteins.
Keywords:
PROTACS
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19.9
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