Response to neoadjuvant chemotherapy as a potential indicator of internal mammary node involvement in early breast cancer

Sophie T. Behzadi

doi:10.1016/j.ijrobp.2026.07.050

Response to neoadjuvant chemotherapy as a potential indicator of internal mammary node involvement in early breast cancer

2026-08-10

0

PRE

AI

S

Sophie T. Behzadi

J

Johannes Wider

J

Jana Nano

S

Sophia Kiesl

L

Luisa Allwohn

S

Sophie Maier

E

Evelyn Klein

G

Georg P. Schmidt

M

Marion Kiechle

M

Marcus R. Makowski

S

Stephanie E. Combs

T

Thomas Huber

K

Kai J. Borm *

DOI：10.1016/j.ijrobp.2026.07.050

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Abstract

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Internal mammary node (IMN) irradiation has the potential to improve the overall survival in nodal positive breast cancer patients. Nevertheless, to achieve these benefits while keeping treatment related morbidity low is technically complex and requires careful patient selection and treatment planning. For this, detection of IMN involvement is of particular importance. This study aims to investigate response of visible IMN to neoadjuvant chemotherapy as potential surrogate for initial IMN involvement.

Response to neoadjuvant chemotherapy as a potential indicator of internal mammary node involvement in early breast cancer

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