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Results of Lucia Keratoprosthesis Implantation in Severe Corneal Disease
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DOI：10.1016/j.ajo.2024.08.035.png)
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Abstract
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center dot PURPOSE: Describe complications, functional success, and retention of the Lucia Keratoprosthesis (KPro). center dot DESIGN: Retrospective interventional case series center dot METHODS: The demographic data, baseline characteristics, complications, functional success, and retention were analyzed for Lucia KPro at the Instituto de Oftalmologia Conde de Valenciana in Mexico City from 2021 to 2023. Multivariate regression analysis and Kaplan- Meier plots were performed to identify associations with functional failure. The main outcome measures were postoperative complications, functional success defined as best-corrected visual acuity (BCVA) >= 20/200 (logMAR 1.0), and device retention rate. center dot RESULTS: Forty-eight eyes of 48 patients (56.88% male) were studied. The mean age at implantation was 57.29 +/- 15.63 years (range 27-91), with a mean followup of 20.5 +/- 8.83 months (range 3-40). Diagnostic indications for implantation included recurrent graft rejection (54.17%), autoimmune disease (20.83%), chemical injury (12.5%), and other (12.5%). At least 1 postoperative complication occurred in 75% of patients, leading to 65 additional interventions (mean number of subsequent procedures: 1.35 +/- 1.3, range 0-5). The preoperative BCVA was 2.40 +/- 0.36 logMAR. At the final followup, 62.5% had achieved functional success and 22.92% had a BCVA of 20/40 (logMAR 0.3) or better. Glaucoma (adjusted OR 469.74, 95% CI 5.02-43939.14, P = .007) and retinal pathology before KPro (adjusted OR 372.38, 95% CI 4.18-33162.11, P = .009) were associated with functional failure. The device remained in place in 95.83% of recipients over the follow-up period. center dot CONCLUSIONS: The Lucia KPro offers functional success in severe corneal diseases and excellent retention in the short to intermediate term. (Am J Ophthalmol 2024;268: 388-394. (c) 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/))
Keywords:
BOSTON TYPE-1 KERATOPROSTHESIS
RETROPROSTHETIC MEMBRANES
OUTCOMES
COMPLICATIONS
BLINDNESS
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