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Resveratrol exerts stage- and sex-specific anti-aging and multigenerational effects via epigenetic and metabolic pathways in Drosophila

delete2026-06-29
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PRE
AI
Q
Quanyong Wu
B
Boya Ouyang
W
Wanning Ma
Y
Yuxuan Zhao
J
Jingyimei Liang
Y
Yi Yuan
H
Hui Cao
J
Jesús Simal‐Gándara
S
Shaoping Nie *
J
Jianbo Xiao *
DOI：10.1016/j.phymed.2026.158531delete
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Abstract

Abstract

En 中文
Resveratrol is a polyphenolic compound with reported anti-aging properties that exhibit complex and context-dependent biological effects, while its potential multigenerational influence remains unclear.
Keywords:
Resveratrol
Drosophila melanogaster
Metabolism
Longevity
Multigenerational inheritance
: PTMs
,
Post-translational modifications
SIRT1
,
Sirtuin 1
ELISA
,
Enzyme-linked immunosorbent assay
NC
,
Normal control
E1
,
1% ethanol
ER10
,
10μg/mL resveratrol
ER50
,
50μg/mL resveratrol
ER100
,
100μg/mL resveratrol
Sod
,
Superoxide dismutase
Cat
,
Catalase
JH
,
Juvenile hormone
H-ESI
,
Heated electrospray ionization
SRM
,
Selected reaction monitoring
DMF
,
Dimethylformamide
SIM
,
Selected ion monitoring
IIS
,
Insulin/IGF signaling
DEGs
,
Differentially expressed genes
GO
,
Gene ontology
KEGG
,
Kyoto encyclopedia of genes and genomes
TCA
,
Tricarboxylic acid
G6P
,
Glucose-6-phosphate
F16BP
,
Fructose-1,6-bisphosphate
PEP
,
Phosphoenolpyruvate
R5P
,
Ribose-5-phosphate
S7P
,
Sedoheptulose-7-phosphate
GSSG
,
Oxidized glutathione
SAM
,
S-adenosylmethionine
PPP
,
Pentose phosphate pathway

Journal

Phytomedicine cover
Phytomedicine
IF:
8.3
Papers:
9.0K
Citations:
3.1W

Organization

N
nanchang university
Scholars:
7.2K
Papers: 2.0K
Citations: 0
I
instituto de agroecoloxia e alimentacion
Scholars:
19
Papers: 7
Citations: 0
F
fuzhou university
Scholars:
3.1W
Papers: 2.1W
Citations: 31
Cited Papers

Cited Papers

Citing Papers

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