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Resveratrol supplementation prior to and during pregnancy in obese rats improves mammary gland maturation; milk composition and offspring metabolism in a sex-specific manner
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DOI：10.1017/S0007114526106333.png)
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Abstract
En 中文
Maternal obesity delays mammary gland maturation; influencing milk composition and neonatal growth. This study investigated whether supplementation of obese rats with resveratrol (Res) improves mammary gland differentiation; milk composition and offspring development. Female Wistar rats were fed either a high-fat diet to induce maternal obesity (MO) or standard chow as control (C). One month before mating; and throughout gestation; half the rats received 20 mg/kg/day Res orally creating two additional experimental groups (CRes and MORes). Milk nutrients and fatty acids were analysed at postnatal day 21 (PND21); maternal body composition; mammary gland weight and fat pad weight were also obtained. Mammary gland morphology and indices of apoptosis were determined. Offspring metabolic parameters were studied at PND36. MO s had increased adiposity; mammary gland weight and showed elevated glucose; TAG and cholesterol levels compared with controls. MORes reduced all these parameters except mammary gland weight. Mammary gland development was delayed and apoptosis increased in MO v. C. Res improved mammary gland development in obese dams. Milk protein/fat ratio; milk; protein and DHA intake decreased in the MO group compared with C; whereas; fat; saturated fat; monosaturated fat and ω-6 fatty acid were increased in MO. Reveratrol treatment restored these parametes in obese dams and significantly reduced adiposity in their offspring. TAG; insulin and HOMA-IR increased in MO offspring but was prevented by Res; which also increased milk intake in controls. In conclusion; preconceptional Res supplementation protects against the negative effects of maternal obesity on mammary gland differentiation; milk composition and offspring metabolism.
Keywords:
Developmental programming
milk
mammary gland
intervention
arachidonic acid
mammary gland
maternal obesity
resveratrol
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