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Retinal hyper-reflective foci link retinal and cortical pathology in paediatric multiple sclerosis

delete2026-07-01
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PRE
AI
C
Curtis M Hay
A
Areej Mahjoub
L
Logi Vidarsson
S
Sahar Soltanieh
M
Matthias Wagner
I
Ines El Naggar
S
Samantha Stephens
N
Nusaybah Khan
B
Birgit Ertl-Wagner
E
E Ann Yeh *
DOI：10.1093/brain/awag235delete
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Abstract

Abstract

En 中文
Pediatric-onset multiple sclerosis is associated with high inflammatory activity early in the disease course, yet sensitive biomarkers of early disease pathology are limited. Hyper-reflective foci on optical coherence tomography have been proposed as markers of inflammation in adult multiple sclerosis, but their relevance in pediatric populations remains unclear. We aimed to identify and quantify retinal layer-specific hyper-reflective foci burden in children with pediatric-onset multiple sclerosis and evaluate associations with MRI markers of disease severity.

Journal

Brain cover
Brain
IF:
11.7
Papers:
1.4W
Citations:
6.3W

Organization

T
The Hospital for Sick Children
Scholars:
1.1K
Papers: 373
Citations: 1
U
university of toronto
Scholars:
14.5W
Papers: 11.9W
Citations: 165
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