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Retromer mediates Ypt7-dependent lipid droplet internalization
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DOI：10.1016/j.celrep.2026.117835.png)
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Abstract
En 中文
• Lipid droplet (LD) internalization depends on the Ypt7-retromer pathway • Under nutrient limitation, Mon1-Ccz1 and Ypt7 target Pdr16-marked LDs • Active Ypt7 recruits retromer to the vacuole-LD interface • Retromer may interact with Vps10 to promote LD internalization and degradation
Keywords:
Mon1-Ccz1
Ypt7
Rab GTPase
retromer
Pdr16
lipophagy
lipid droplets
membrane contact sites
vacuole
invagination
CP: cell biology
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