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Retrospective Evaluation of the OECD Adopted In Vitro Skin Irritation/Corrosion Tests for Agrochemical Formulations
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DOI：10.1016/j.yrtph.2026.106122.png)
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Abstract
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• OECD test guidelines (TG) 431 and 439 do not explicitly include agrochemicals. • We evaluated in vitro data (TG 431 and/or 439) for 187 agrochemical formulations. • We also evaluated the GHS concentration threshold (CT) approach. • TG 439 and the CT approach were predictive of in vivo mild/non-irritant categories. • These methods could greatly reduce animal use for skin irritation testing.
Keywords:
in vitro skin irritation
OECD test guidelines
agrochemical formulations
GHS concentration threshold
animal use reduction
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