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Reversing cisplatin-induced immunosuppression with a selenium-integrated nanoliposome to synergize natural killer cell chemoimmunotherapy for cervical cancer
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DOI：10.1016/j.nantod.2026.103111.png)
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Abstract
En 中文
• P/U@LNP, a liposomal nanomedicine, enables sustained stability, enhanced cellular uptake, lysosomal escape, prolonged circulation, and reduced toxicity. • P/U@LNP inhibits HeLa cell growth by inducing ROS elevation and cell cycle arrest, achieving tumor suppressive effects. • P/U@LNP enhances NK92 cell cytotoxicity by upregulating activating receptors and promoting perforin, granzyme, and cytokine secretion. • P/U@LNP combined with NK92 cells kills HeLa cells through immune suppression relief, providing a rationale for nano‑immunotherapy against cervical cancer.
Keywords:
ATCC
American type culture Collection
BCA
Bicinchoninic acid assay
Bcl-2
B-cell leukemia/lymphoma 2 protein
CCK-8
Cell counting kit-8
CCRT
concurrent chemoradiotherapy
CDDP
cisplatin
C-PARP
cleaved poly-ADP ribose polymerase
DCFH-DA
2′,7′-dichlorofluorescin diacetate
DEGs
differentially expressed genes
DMEM
dulbecco's modified eagle medium
DMF
N,N-dimethylformamide
DOTAP
1,2-dioleoyl-3-trimethylammonium-propane chloride salt
DR4
death receptor 4
DR5
death receptor 5
EPR
enhanced permeability and retention effect
FADD
Fas-associating protein with a novel death domain
FBS
fetal bovine serum
GEO
Gene Expression Omnibus
GPXs
glutathione peroxidases
ICP-MS
inductively coupled plasma mass spectrometry
IFN-γ
interferon-gamma
IL-10
interleukin-10
IL-1β
interleukin - 1β
MTT
thiazolyl blue tetrazolium bromide
NK
natural killer cell
P-ATM
phosphorylated ataxia-telangiectasia mutated protein
P-ATR
phosphorylated ataxia-telangiectasia and rad3-related
P-Bad
phosphorylated Bcl-2-associated death promoter
P-Bax
phosphorylated Bcl-2-associated protein x
PBS
phosphate buffered saline
P-Chk1
phosphorylated checkpoint kinase 1
P-Chk2
phosphorylated checkpoint kinase 2
PD-L1
programmed cell death ligand 1
ROS
reactive oxygen species
TEM
transmission electron microscope
TrxR
thioredoxin reductase
UsSe
ultrasmall selenium
Cervical cancer
Chemoimmunotherapy
Liposome nano-delivery system
Reactive oxygen species
NK cell therapy
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