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Rhinovirus-Infected Preschool Children with Problematic Wheeze Have Lung Eosinophilic Inflammation
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DOI：10.1016/j.jaci.2026.07.002.png)
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Abstract
En 中文
Rhinovirus (RV) infections are important triggers of wheezing illnesses in children and in infants are associated with the later development of asthma. In preschool children with treatment-refractory wheeze, we reported ∼30% had an active but silent RV infection, most with mixed lung neutrophilia and eosinophilia. This led us to speculate that RV infection might support the future inception of asthma through type 2 (T2) inflammatory pathways.
Keywords:
Rhinovirus
type 2 inflammation
eosinophils
asthma
problematic wheeze
BAL
bronchoalveolar lavage
cACT
childhood asthma control test
CCS
corticosteroids
CRP
C-reactive protein
EDN
eosinophil-derived neurotoxin
IL
interleukin
ml
milliliter
ng
nanogram
NS
not significant
POSTN
periostin
PMN
neutrophil
RNA-seq
RNA sequencing
RV
rhinovirus
T2
type 2
TSLP
thymic stromal lymphopoietin
UVA
University of Virginia
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