.png){kind=icon}
.png){kind=icon}
Return
Ribosome Evolution and Structural Capacitance
.png){kind=icon}
OA
AI
DOI：10.3389/fmolb.2019.00123.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
In addition to the canonical loss-of-function mutations, mutations in proteins may additionally result in gain-of-function through the binary activation of cryptic structural capacitance elements. Our previous bioinformatic analysis allowed us to propose a new mechanism of protein evolution - structural capacitance - that arises via the generation of new elements of microstructure upon mutations that cause a disorder-to-order (D -> O) transition in previously disordered regions of proteins. Here we propose that the D -> O transition is a necessary follow-on from expected early codon-anticodon and tRNA acceptor stem-amino acid usage, via the accumulation of structural capacitance elements - reservoirs of disorder in proteins. We develop this argument further to posit that structural capacitance is an inherent consequence of the evolution of the genetic code.
Keywords:
structural capacitance
ribosome evolution
protein disordered region
disorder-order transition
codon-anticodon
genetic code
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
4
Papers:
6.0K
Citations:
2.0W