Right Caudal Hippocampal Structural–Functional Coupling Alterations in Major Depressive Disorder: An Exploratory Pattern Linking Childhood Trauma and Executive Function Alterations at Lower Depression Severity

Jing Wang

doi:10.1016/j.jpsychires.2026.05.008

Right Caudal Hippocampal Structural–Functional Coupling Alterations in Major Depressive Disorder: An Exploratory Pattern Linking Childhood Trauma and Executive Function Alterations at Lower Depression Severity

2026-05-08

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DOI：10.1016/j.jpsychires.2026.05.008

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• Altered SC-FC coupling was observed in first-episode, drug-naïve youth with MDD. • Nineteen regions showed significant SC-FC coupling differences from HCs. • Exploratory associations linked SC-FC coupling to CTQ and SCWT reaction time in MDD. • Right caudal hippocampal coupling showed a conditional indirect association.

Keywords:

Structural–functional coupling

Major Depressive Disorder

Hippocampal alterations

Childhood trauma

Executive function

Right Caudal Hippocampal Structural–Functional Coupling Alterations in Major Depressive Disorder: An Exploratory Pattern Linking Childhood Trauma and Executive Function Alterations at Lower Depression Severity

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