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RIPK4 knockout enhances the antitumor effects of melatonin pretreatment in melanoma cells in vitro and in a xenograft model in zebrafish.
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DOI：10.1016/j.mce.2026.112810.png)
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Abstract
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• Loss of RIPK4 leads to upregulation of melatonin receptors MT1 and MT2 • RIPK4.KO cells showing greater sensitivity to melatonin-induced apoptosis • Melatonin pretreatment inhibits melanoma cell proliferation and slows tumor growth in Danio rerio. • The combination of RIPK4 knockout and melatonin pretreatment produces the strongest inhibition of melanoma cell proliferation, showing an additive effect.
Keywords:
RIPK4
melatonin
MT1
MT2
melanoma
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