.png){kind=icon}
.png){kind=icon}
Return
Risk factors for adverse events or use of high-potency corticosteroids in non-infectious uveitis: a Japan claims database study (J-CAT2)
.png){kind=icon}
OA
AI
S
K
T
T
S
M
T
M
T
Y
T
M
K
K
K
H
DOI：10.1080/25785826.2026.2693410.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
The J-CAT2 study (#jRCT1030240195) aimed to evaluate treatment and patient factors associated with risk of complications/adverse events (AEs) or high corticosteroid exposure in patients with non-infectious uveitis (NIU) using advanced quantitative and visual analytical approaches. The study included data from a nationwide insurance claims database in Japan. Patients with NIU treatment-related claims (2016–2023) were included (n = 98,842). A nested case-control design was used to evaluate patient factors associated with complications/AEs or high corticosteroid exposure. Multivariable logistic regression and decision-tree analyses were performed. Sub-Tenon’s corticosteroid injections were associated with dose-dependent increased odds of glaucoma treatment and cataract surgery (OR [95% CI]: 1 sub-Tenon’s injection, 3.27 [2.60–4.11] and 3.19 [2.39–4.27], respectively; ≥2 sub-Tenon’s injections, 5.54 [4.03–7.60] and 4.86 [3.44–6.85], respectively). Macular edema was the most likely factor associated with ≥2 sub-Tenon injections. Vogt-Koyanagi-Harada disease and sarcoidosis were the most likely factors associated with medium-to-high-dose corticosteroids and long-term oral corticosteroids. The J-CAT2 study used a novel, quantitative and visual framework to understand associations between dose, frequency, and duration of corticosteroid treatment and complications/AE risk in NIU. These findings suggest that optimization of corticosteroid administration protocols and exploration of alternative therapeutic strategies/targeted treatment approaches are necessary to mitigate complication risks.
Keywords:
Cataract
corticosteroids
glaucoma
Japan
macular edema
non-infectious uveitis
Journal
IF:
2.9
Papers:
92
Citations:
497
Organization
Cited Papers