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RNA-binding proteins in the mouse lens: Functional classifications, expression profiling, and interaction studies of Carhsp1 with crystallin mRNAs
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DOI：10.1016/j.ydbio.2026.04.017.png)
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Abstract
En 中文
• RNA-binding proteins (RBPs) act as key regulators of gene expression throughout lens morphogenesis • Transcriptomic profiling identified Carhsp1, Igf2bp1/ZBP1 and Ybx1 amongst the most highly expressed lens RBPs • Carhsp1-crystallin mRNA interactions were validated in cultured mouse lens cells • Our findings enable targeted genetic and molecular studies of RBPs to probe lens fiber cell differentiation
Keywords:
Carhsp1
crystallin mRNA
lens
RNA-binding proteins
mRNA stability
single molecule fluorescence.RNA hybridization
CSD
Cold-shock domain
FIMO
Find Individual Motif Occurrences
FISH
fluorescence in situ hybridization
iSyTE
Integrated Systems Tool for Eye gene discovery
GO
Gene Ontology
KH
K homology
RBP
RNA-binding protein
RRM
RNA recognition motif
smFISH
single molecule RNA FISH
UTR
untranslated region
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