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RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity
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DOI：10.1016/j.molcel.2026.06.036.png)
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Abstract
En 中文
• REXO4 processes R-loops by 3′–5′ exonucleolytic degradation of the RNA strand • m6A modification within R-loops dictates promoter-proximal REXO4 localization • REXO4-dependent R-loop clearance restrains tumor immune surveillance • Targeting REXO4 synergizes with anti-PD-1 therapy to suppress tumor progression
Journal
IF:
16.6
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1.0W
Citations:
8.5W
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