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Role of the GAPDH-Mediated Glycolysis-Senescence Axis in Osteoarthritis Chondrocytes and Its Modulation by Semaglutide

delete2026-05-08
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刘大猛 cover
刘大猛 (Dameng Liu) *
L
Leilei Wang
L
Lin Zhu
Y
Yuanhang Wang
L
Lijia Pei
DOI：10.1016/j.jbspin.2026.106072delete
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Abstract

Abstract

En 中文
• Cellular senescence is a central pathological feature in osteoarthritis chondrocytes. • GAPDH acts as a key hub linking glycolysis and senescence in OA. • Semaglutide restores GAPDH, reduces inflammation and senescence markers, and improves chondrocyte function.
Keywords:
GAPDH
glycolysis
senescence
osteoarthritis
chondrocytes

Journal

Joint Bone Spine cover
Joint Bone Spine
IF:
4.3
Papers:
4.2K
Citations:
4.8K

Organization

B
bengbu medical university
Scholars:
1.7K
Papers: 498
Citations: 52
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