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Roles of group 2 innate lymphoid cells in development of steroid-resistant severe asthma and their therapeutic targets
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DOI：10.1016/j.imlet.2026.107174.png)
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Abstract
En 中文
• Steroid-resistant ILC2s actively contribute to airway remodeling in severe asthma. • JAK-STAT5-Bcl-xL signaling mediates steroid resistance in ILC2s. • PI3K-Akt-mTORC1 signaling also contributes to steroid resistance in ILC2s. • Coactivation of these pathways enforces a robust steroid-resistant ILC2 phenotype. • Epithelial-ILC2 signaling is a promising therapeutic target in severe asthma.
Keywords:
ILC2s
steroid resistance
severe asthma
JAK-STAT5-Bcl-xL signaling
PI3K-Akt-mTORC1 signaling
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