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ROS-responsive hydrogel for treating pulpitis: Localized immunometabolic regulation by dimethyl itaconate promotes reparative dentin formation
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DOI：10.1016/j.colsurfb.2026.115783.png)
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Abstract
En 中文
• A ROS-responsive injectable hydrogel for DMI delivery is developed. • DMI suppresses inflammation and oxidative stress in DPSCs. • DMI does not directly promote odontogenesis under inflammation. • DMI restores odontogenesis via macrophage-mediated modulation. • The hydrogel enhances reparative dentin formation in vivo.
Keywords:
ROS-responsive hydrogel
Dimethyl itaconate
Pulpitis treatment
Immunometabolic regulation
Reparative dentin formation
Journal
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IF:
5.6
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1.4W
Citations:
4.2W
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