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Runx3 instructs Aire+ mTEC development, TSA gene expression, and central tolerance
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DOI：10.1016/j.jaut.2026.103573.png)
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Abstract
En 中文
• Deletion of Runx3 in thymic epithelium leads to loss of Aire + mTECs and an increase in immature Ccl21a-expressing mTECs. • Runx3-deletion leads to loss of tissue specific antigen expression, autoimmunity, and increased escape of autoreactive T cells from the thymus. • Runx3 affects signaling pathways important for inducing Aire + mTEC development, including CD40 and NF-kb.
Keywords:
Runx3
Aire+ mTECs
central tolerance
tissue-specific antigens
thymic epithelium
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