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Safety and efficacy of low-dose, cord blood-derived CD19 CAR-NK cells with 4-1BB co-stimulation in refractory systemic lupus erythematosus

delete2026-07-22
delete0
PRE
AI
Z
Zhiru Zeng
W
Wen Lei
W
Wenhai Deng
M
Mo Chen
W
Weihong Xu
L
Liang Zhu
J
Jing Xue
M
Min Yuan
J
James Q. Wang
Q
Qian Ye
S
Songzhao Zhang
Q
Qiaohong Wang *
W
Wenbin Qian *
H
Huaxiang Wu *
DOI：10.1016/j.medj.2026.101226delete
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Abstract

Abstract

En 中文
• Allogeneic CD19-BBz CAR-NK cells show excellent safety in refractory SLE • All five patients with refractory SLE achieved SRI-4 response and LLDAS • CAR-NK therapy induces profound B cell depletion and naive-dominant reconstitution • Low-dose CAR-NK cells suffice for sustained B cell reset and durable clinical response

Journal

Med cover
Med
IF:
11.8
Papers:
771
Citations:
2.2K

Organization

H
hangzhou rong-gu biotechnology limited company
Scholars:
2
Papers: 1
Citations: 0
W
wenzhou medical university
Scholars:
6.2K
Papers: 1.6K
Citations: 0
Z
zhejiang university
Scholars:
17.0W
Papers: 11.9W
Citations: 152
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